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Tegafur Uracil is a chemotherapy drug usually given to treat colon and rectal cancer. It's also sometimes called Uftoral. The capsules should be taken three times a day at regular intervals. They should be swallowed whole and taken either an hour before or an hour after food. A tablet called calcium folinate is given with tegafur uracil. This helps to make tegafur-uracil work more effectively. Both tablets should be taken at the same time.